Lorena Andrea was born in London, to Spanish and Colombian parents. Making her fluent in English and Spanish. Andrea made her feature film debut in Michael Noer's 2017 rendition of the 1973 classic Papillon (2017) as Lali, a Wayuu Indian woman who rescues Papillon Charlie Hunnam and nurses him back to health. Lorena landed her first leading role in the film No Man's Land (2019), a western set in 1866 Texas. In 2020, she began starring in Netflix's Original comic book series Warrior Nun (2020) as Sister Lilith, where she performed the majority of her own stunts. Lorena played mermaid princess Perla, one of Ariel's sisters in the 2023 live-action film adaptation of Disney's The Little Mermaid (2023).