Blanco started as a theater actor, most notably under the direction of Norma Aleandro in Cyrano de Bergerac as well as having roles in Shakespeare plays like A Midsummer Night's Dream and Macbeth. His screen debut was in Victoria 392, where he met and befriended director Juan José Campanella and fellow screenwriter Fernando Castets. Campanella and Castets would later on write roles specifically for him in a trilogy of movies that starred Ricardo Darín as the protagonist and Blanco as his friend: El Mismo Amor, la Misma Lluvia (1999), El Hijo de la Novia (2001) and Luna de Avellaneda (2004). Blanco went on to collaborate a fifth time with Campanella in the TV series, Vientos de agua (2006).