Desde hace años, Maddie, Helen y Dana Sue se apoyan en su amistad para sobrellevar los altibajos en sus relaciones, familias y carreras en el pequeño pueblo de Serenity.

A Hispanic middle-class family moves back to Miami after living in California to take care of their recently widowed Abuela. Little do they know their new house is the infamous Bradford house which is haunted by two mischievous ghosts. Hilarious situations ensue as the family settles in, romance unfolds, over-zealous ghost hunters stalk the house, Abuela becomes more and more superstitious all the while high schoolers plan to throw a big Halloween party at the Bradford house.