Born in Georgia, Kaylee Hottle comes from an all-Deaf family, spanning four generations of Deaf relatives on her father's side. Her native fluency in American Sign Language has provided her with opportunities to perform in commercials such as the Glide app public service announcement (directed by Jules Dameron, 2016) and "Mother's Day" (for Convo Relay, 2017). She also appeared in "10 Deaf Children: One Powerful Message" (directed by Sheena McFeely and produced by ASL Nook, 2018), and starred in the film Godzilla vs. Kong (2021) as Jia.